During cell development, gene expression is regulated by both external stimuli and internal chromatin states, and proper gene expression is crucial for normal cell development. This research uses a common model organism: Drosophila melanogaster, to observe the effects of the gene Scrawny (Scny) on the development of ovaries and regulation of histones, and to explore the potential relevance of this gene in human biology. Using RNA interference (RNAi) driven by a cell-specific promoter, we investigated the functions of Scny. The results show that Scny knockdown cells have larger nuclei, premature entry into the endocycle stage, and elevated H3K4Me3 signals, at the same time, multi-nucleated cells were also observed. Except for the value in basic biology, the results observed also share many features with polyploid giant cancer cells (PGCCs), suggesting that Scny research may provide insights into human cancer development.