This study investigates the effects of acute restraint stress on cognitive function in mice and examines whether the experimental drug J4 can mitigate potential cognitive impairment. The experiment was conducted in two parts. The first phase, a pilot study, involved 10 mice exposed to the stressor without the drug. The second phase divided 20 similar mice into four groups based on stress exposure and J4 administration. We performed common behavioral and cognitive tests, including the Open Field Test, Forced Swimming Test, and Novel Object Recognition Test. Our results showed that both acute restraint stress and drug J4 did not enhance cognitive function. Interestingly, acute restraint stress helped reduce anxiety and depression levels in mice. The effects of J4 varied depending on the stress model. In the tail suspension test without stress, J4 increased depressive-like behavior. However, in the forced swimming test without stress, J4 decreased depressive-like behavior. These findings suggest that the effects of drug J4 on anxiety and depression levels differ across various stress paradigms.