Enzymes are critical to human health, and abnormal concentrations in body fluids often serve as an early indicator for diseases like cancer. Traditional detection methods, such as colorimetric or electrochemical analyses, are limited by low sensitivity, high sample interference, and the requirement for expensive instruments or unstable chemicals, making it difficult to accurately detect minor changes in enzyme activity. To address these limitations, we propose a highly sensitive and versatile enzyme activity detection platform utilizing Metal-Organic Frameworks (MOFs), which are porous crystalline materials engineered to act as nanozymes. MOF nanozymes offer enhanced stability and simplified production compared to natural enzymes. Our proposed technique is ""product-dependent,"" operating on the principle that the MOF nanozyme's catalytic function is inhibited by the products of the target enzyme's hydrolysis reaction. Specifically, the active enzyme produces hydrolysis products that subsequently deactivate the MOF nanozyme, causing a measurable decrease in the colorimetric signal produced by the MOF. This inverse correlation between the target enzyme's activity and the colorimetric signal allows for highly sensitive detection. The platform's versatility stems from the ability to tune the MOF's composition and structure to specifically detect various enzymes and adapt to different environments, overcoming the inherent drawbacks of existing assays. Following a thorough analytical performance evaluation, including determining the limit of detection (LOD) and sensitivity, our immediate next step is to translate this technology into portable, low-cost diagnostic devices such as test strips. This will enable rapid, economical, and universal disease early screening and monitoring, providing an accessible and powerful diagnostic tool for global healthcare.