This study investigated the effect of GDP-fucose transporter (SLC35C1) expression on thyroid cancer cell migration and healing, and explored the interaction between thyroid cancer cells and bone marrow cells. Results showed that SLC35C1 expression was low in high-grade thyroid cancers, and higher expression correlated with decreased migration and healing abilities. We found that increased SLC35C1 activity in cancer cells, in the bone environment, elevates the expression of ABCG1, ABCC2, ABCC3, BLVRA, and HMOX1, increasing bilirubin metabolism and inhibiting osteophagocytic apoptosis, thereby promoting osteophagocytosis and exacerbating bone destruction. We also found that SLC35C1 promotes osteophagocytic differentiation by upregulating MCSF and inhibits osteophagocytic apoptosis by affecting bilirubin metabolism. These results suggest that bone tissue may play a key role in thyroid cancer bone metastasis by upregulating SLC35C1 in thyroid cancer cells, retaining undifferentiated cancer cells in the bone and promoting osteophagocytic activity and bone breakdown.